Transfusion-transmitted HTLV-I/II infection in patients undergoing open-heart surgery.
نویسندگان
چکیده
Sera from 5,244 blood donations collected between 1979 and 1987 were screened for antibody to HTLV-I with an enzyme immunoassay (EIA) whose result was confirmed with a two-step procedure including Western blot (WB) and radio immunoprecipitation. Of 20 repeatedly reactive samples, two were confirmed positive for HTLV-I infection. These blood units were transfused to patients undergoing cardiac surgery. Both recipients of the confirmed anti-HTLV-I positive units were infected with HTLV-I as evidenced by antibody seroconversion. In contrast, six recipients of EIA positive, WB indeterminate blood and nine recipients WB negative blood were not infected with HTLV-I. These results confirm a low prevalence of HTLV-I infection in US blood donors, the capacity of infected units to transmit the virus to recipients, and the importance of an appropriate confirmatory assay.
منابع مشابه
Prevalence of antibodies to human T-lymphotropic virus types I and II among Saudi Arabian blood donors.
In 1980 and 1982, Gallo et al. described the isolation of human T-cell lymphotropic virus type I (HTLV-I) and type II (HTLV-II). In the majority of cases, infection with these viruses does not cause diseases. However, HTLV-I infection has been etiologically associated with neoplastic diseases and a variety of demyelinating neurologic disorders. The association of HTLV-II with leukemia pathogene...
متن کاملTransfusion-Transmitted Viruses in Individuals with β Thalassemia Major at Northeastern Iran, a Retrospective Sero-Epidemiological Survey
Background: Thalassemia syndromes are the most common genetic disorders in the world. They happen due to genetic defects in process of haemoglobin synthesis, and would be classified to many groups mainly α and β, based on the kind of defect. Anemia is the main clinical manifestation of this phenotype of disorder. In order to correct the chronic anemia in thalassaemic individuals, they may need ...
متن کاملBlood transfusion rate in patients undergoing prostate surgery
Background: Benign prostatic hyperplasia is defined as enlargement of the prostate gland in the presence of symptoms of urinary without evidence of malignancy. For patients who have failed medical management as first line of therapy, surgical intervention will be done as the treatment. Hemorrhage is one of the most dreadful and serious complications of Prostate surgery. Bleeding can often be si...
متن کاملPrevalence of Seropositivity for Human T lymphocytes Virus in Patients with Hereditary Bleeding Diseases in Population of West Azerbaijan
Background and Aims: Human T-lymphotropic virus (HTLV) is a human retrovirus which has been known to cause adult T-cell leukemia/lymphoma and some other inflammatory disorders. Patients with hereditary bleeding diseases are at high risk for these viruses. In this study, we evaluated serological HTLV-I/II infection among these patients in west Azerbaijan of Iran. Material and Methods: We stud...
متن کاملEffect of Instructional Videos on Postoperative Respiratory Function in Patients Undergoing Off-Pump Open Heart Surgery
Background: Respiratory function in patients undergoing open heart surgery is disrupted after surgery. Patient education on managing complications can reduce occurrence or severity of them. A variety of educational tools has been introduced, but there are controversies about the most appropriate tools. Aim: Determine the effect of instructional videos on respiratory function of the patients af...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 75 3 شماره
صفحات -
تاریخ انتشار 1990